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KMID : 0613820140240030290
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Journal of Life Science
2014 Volume.24 No. 3 p.290 ~ p.296
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Anxiolytic Effects of Quercetin: Involvement of GABAergic System
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Jung Ji-Wook
Lee Seung-Heon
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Abstract
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The present experiment investigated putative anxiolytic-like effects of quercetin using an elevated plus-maze (EPM) and hole-board apparatus test in mice. Quercetin is a flavonoid widely distributed in nature. Quercetin (1.25, 2.5, 5, or 10 mg/kg) was orally administered to ICR mice 1 h before a behavioral evaluation in the EPM. Control mice were treated with an equal volume of vehicle, and positive control mice were treated with buspirone (2 mg/kg, i.p.). The mice administered quercetin (5 mg/kg) spent a significantly longer percentage of time in the open arms of the EPM and their percentage of entries into the open arms was significantly increased compared to the vehicle-treated controls (p<0.05). The anxiolytic-like activities of quercetin were antagonized by trans-4-aminocrotonic acid (a GABA_A-p agonist, 20 mg/kg) but not by flumazenil (a GABA_A antagonist, 10 mg/kg) or WAY-100635 (a 5-HT1A antagonist, 0.3 mg/kg). Moreover, there were no changes in the locomotor activity or myorelaxant effects in any group compared with the vehicle-treated controls. In the hole-board apparatus test, the number of head-dips increased significantly in the single treatment with quercetin (5 mg/kg) group compared to the vehicle-treated controls (p<0.05). These findings suggest that quercetin can promote anxiolytic-like activity, mediated by the GABAergic nervous system, in mice.
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KEYWORD
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Anxiety, GABA_A-p, mice, quercetin, trans-4-aminocrotonic acid
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